Abstract
Due to an increased use of gold nanoparticles (AuNPs) in various consumer products we aimed to investigate the cytotoxic impact of AuNPs found in a commercial dietary supplement drink (SD-AuNPs). The cytotoxic impact of SD-AuNPs was determined in mouse connective tissue fibroblasts (L929). The cells were treated with different concentrations of SD-AuNPs (0.2, 0.5, 10, 20, 30, 40, and 50 µg/mL). The results indicated that the toxicological effect of SD-AuNPs on L929 cells occurred in a dose-dependent manner. Significant reduction of cell viability was found in L929 cells treated with 10, 20, 30, 40, and 50 µg/mL SD-AuNPs for 24 h. L929 cells treated with 40 and 50 µg/mL SD-AuNPs produced significant intracellular reactive oxygen species and TNF-α. High levels of intracellular uptake of these compounds were also observed in L929 cells treated with 50 µg/mL SD-AuNPs.
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