Abstract
The acute pathotoxicity of diethanolamine (D) and diethanolamine-rutin (DR) was investigated in mice. Toxic doses produced depressant effects similar to those of ethanol. In mice the ip LD50 values for D and DR were 2.3 g/kg and 2.4 g/kg, respectively. A dose of 0.5 g/kg of DR given ip daily for 5 days, increased serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamicpyruvic transaminase (SGPT) activities. Acute doses of DR revealed a dosedependent effect on increasing serum transaminase levels. Ethanol and DR are synergistic with respect to alteration of both SGOT and SGPT activities. LD50 doses of D and DR produced hepatic steatosis and cellular degeneration. These findings indicate that D and DR are toxic at about twice the dose reported to protect rodents against acute ethanol-induced motor incapacitation.
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