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Abstract
Abstract 1. Hematology and blood biochemistry parameters were examined in order to determine the metabolic or endocrine disturbances caused by colchicine intoxication in sea bass ( Dicentrarchus labrax ) aged 1 + . The detection of non-lethal effects of colchicine requires the use of a broad concentration range (6.25–1020 mg 1 −1 ). 2. The 48-hr lc 50 , was 1020 mg 1 −1 , a value which is close to that previously reported in the reference fresh water fish Brachydanio rerio . Exposure to 50 and 125 mg −1 colchicine for 48 hr resulted in 100% mortality one week after treatment. 3. Colchicine involves the concomitant increase of packed cell volume and hemoglobin concentration in whole blood, in the concentration range of 12.5–1020 mg 1 −1 . 4. The activity of erythrocyte antioxidant enzymes undergoes low amplitude variations after 48-hr exposure to colchicine, regardless of concentration. Two days after recovery, decreased SOD, and increased catalase and peroxidase activities were shown.
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