Toxicity of 90 Y in Relatively Insoluble Fused Aluminosilicate Particles When Inhaled by Mice

Abstract

LUNDGREN, D. L., HAHN, F. F., AND MCCLELLAN, R. O. Toxicity of 90Y in Relatively Insoluble Fused Aluminosilicate Particles When Inhaled by Mice. Radiat. Res. 88, 510-523 (1981). A life span study in mice of the toxicity of a short-half-lived (64.2 hr) #-emitting radionuclide, 90Y, inhaled in insoluble fused aluminosilicate particles was conducted. Mice were exposed to achieve initial lung burdens between 1 and 140 MCi of 90Y with each microcurie of 90Y deposited in lung delivering an absorbed lung dose of 150 rad. The cumulative survival rates of mice in groups with initial lung burdens of 1 to 10 eCi (1100 ? 380 rad to lungs) and 11 to 20 ACi (2300 ? 400 rad to lungs) were not significantly different from that of control mice. Initial lung burdens of more than 20 MCi (>3000 rad to lungs) resulted in radiation pneumonitis and a significant shortening of the life span. The incidences of all lung tumors and other lesions in mice exposed to 90Y in fused aluminosilicate particles were similar to those of the control mice, except pulmonary adenomas, found more frequently in groups of mice with initial lung burdens of 1 to 10 and 11 to 20 jACi. The early occurring biological effects observed in mice in this study were similar to those observed in beagle dogs exposed to 90Y in the same form.