Abstract
Exposure of isolated rat hepatocytes to α-naphthylisothiocyanate (ANIT) results in time and dose-dependent decreases in glutathione (GSH), ATP and cell viability. When taurine (15 m m) was added to cells no protection was afforded and a drop in the initial levels of GSH was also found. Prior treatment of rats with β-alanine (3% in drinking water) did not increase ANIT toxicity, although taurine levels significantly dropped in cells. When 15 m m cysteinesulfinate was added to taurine depleted cells, some protection was afforded with a smaller drop in GSH than for cells incubated with buffer or taurine. The taurine pathway may thus play a protective role in ANIT cytotoxicity in isolated hepatocytes.
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