Abstract
Background and Aims: Atherosclerosis is a non-resolving inflammatory condition that underlies major cardiovascular diseases. Docosahexaenoic acid (DHA) is a natural omega 3 fatty acid component of algae oil that acts as a precursor of several anti-inflammatory compounds. Our research group has previously developed a lipid-core nanocapsule with DHA constituting the nucleus and anti-PECAM-1 on its surface, in order to target the inflamed endothelium. However, toxicity must be evaluated before the nanocapsules are in vivo applied.
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