Abstract
In this study, BPA was selected as the research object to explore the effect of BPA on the development of reproductive system and its damage mechanism in the weaning F1 male offspring SD rats. The development of sexual organs and the change of sex hormone level in F1 male offspring were observed from the day of pregnancy when BPA of 50mg / kg, 100mg / kg and 200mg / kg was administered to the mother rats to the weaning period. The results showed that the serum PRL level of F0 parent rats in BPA group increased significantly at the end of weaning period, and the serum E2 level of 100 mg / kg and 200 mg / kg groups increased significantly. In F1 offspring, the dose of BPA was positively correlated with the level of serum E2, negatively correlated with the level of serum T, FSH decreased in 200mg / kg BPA group, and the organ coefficient of testis decreased significantly in 100mg / kg and 200mg / kg groups compared with the control group.
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