Abstract
Malathion toxicity in suckling Wistar rats and its effects on cholinesterases and carboxylesterases were studied. The 1-day-old pups were found to be nine times more susceptible to malathion than the 17-day-old pups. Based on the hydrolysis of indophenyl acetate, liver esterases were markedly inhibited by malathion from 0.5 to 24 hr after dosing. Brain cholinesterases were also inhibited within 0.5 hr but showed a sign of recovery 3 hr after malathion dosing. The development of cholinesterases and carboxylesterases in different organs was followed in rats 1–84 days old.
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