Abstract
Rauwolfia canescens yields another alkaloid which possesses sedative and strong hypotensive activity. This newly isolated ester alkaloid has been termed 11- desmethoxyreserpine. Unlike reserpine, this alkaloid does not yield reserpic acid upon hydrolysis. The acid resulting as a hydrolysis product of 11-desmeth- oxyreserpine has been termed raunormic acid, whose physical properties differ markedly from those of reserpic acid. Acute oral, intraperitoneal, and chronic oral toxicity studies indicate that 11-desmethoxyreserpine exhibits in the test animal a favorable therapeutic index, thus assuring relative safety, warranting further pharmacologic and clinical studies.
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