Abstract
IT has recently been reported1 that the 5,6,7,8-tetrahydro derivatives of the folic acid antagonists aminopterin, N10-formylaminopterin and amethopterin have a greater inhibitory action on the growth of Streptococcus faecalis R and Pediococcus cerevisiae than the unreduced analogues. It was therefore of interest to determine whether the greater inhibitory action found in the bacterial system is also reflected in a mammalian system, by an increase in host toxicity and/or anti-leukaemic activity.
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