Abstract
Toxicity (acute and subacute) assessment and in-vivo antiurolithiatic activity of ethanolic extract of Caesalpinia bonducella seed in albino Wistar rat
Highlights
Urolithiasis termed kidney stone or nephrolithiasis, is a common worldwide disease with a high prevalence and recurrence rate
The efficacy of ECB at dose of 200 and 400 mg/kg was studied in ethylene glycol, glycolic acid, and sodium oxalate induced urolithiasis in rats and marketed cystone tablet at a dose of 750 mg/kg was used as the standard drug
In order to investigate the effect of medicinal plants on urolithiasis, we chosen C. bonducella that have been claimed to have diverse therapeutic characteristics
Summary
Urolithiasis termed kidney stone or nephrolithiasis, is a common worldwide disease with a high prevalence and recurrence rate. Chronic diseases, including diabetes mellitus, obesity, kidney disease, metabolic disorder, and hypertension, have a high tendency to form stones compared with healthy people (Besiroglu and Ozbek, 2019). It causes pyelonephritis or acute renal failure and severe acute back pain (Namburu et al., 2017; Yasui et al, 2017). Urolithiasis typically occurs between the age of 20 and 60 years and is more occurrences in hot climates. It affects nearly 10% of men and 6% of women over their lifetime. Struvite stones are called triple phosphate or infection stones or magnesium ammonium phosphate and develop
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