Toxic potential of sodium hypochlorite in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9

Abstract

Sodium hypochlorite (NaOCl) at a final concentrations of 0.025, 0.050, 0.075 and 0.1 M was mixed in the diet and the third instar larvae were allowed to feed on it for 24 h. The larvae exposed to 0.050, 0.075 and 0.1 M of NaOCl showed a dose-dependent significant increase in the activity of β-galactosidase, tissue damage, oxidative stress markers, DNA damage and Caspase-3 and 9 activities. Larvae exposed to 0.025 M of NaOCl did not show any toxic effect in the third instar larvae. The NaOCl is toxic at 0.05, 0.075 and 0.1 M in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.