Abstract
Identification of highly toxic polychlorinated dibenzofurans (PCDFs) in commercial PCBs has contributed to the belief that they play a major role in the PCB toxicity. However, Quantitative Structure Activity Relationship (QSAR) studies have indicated that PCB congeners with chlorine substitution at both para and two or more meta positions resemble 2,3,7,8-tetrachlorodibenzo-p-dioxin (T/sub 4/CDD) in their biologic and toxic effects due to their coplanarity. The relative toxic potential of these PCB isomers in wild animals such as Forster's tern, marine mammals and Snapping turtle has been emphasized. Some members of these toxic congeners were also identified and quantitated in commercial PCBs. However, there is no serious effort to evaluate the toxic potential of these PCB congeners in commercial PCB mixtures. Hence an isomer-specific toxic evaluation was attempted in those mixtures to understand the chemical factors behind their toxicity.
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