Abstract
The present work aimed to evaluate acute and sub-acute toxicity of cortex cassava crude extract containing scopoletin and cyanide. The limit test method of OECD at 2000mg/kg was used to determine the LD50 of the crude extract in female Wistar rats, and the sub-acute toxicity was conducted in broilers by incorporating their feed with the cortex powder at 2mg, 4mg and 8mg of powder per 100g of standard food, corresponding to MIC, 2MIC and 4MIC: those concentrations, respectively, corresponded to .07μg, .14μg and .28μg of scopoletin and 2.8μg, 5.6μg and 11.2μg of cyanide. An oral LD50 greater than 2000mg/kg was obtained, and the effective antifungal dose was non-toxic. No changes were observed in the rate of biochemical parameters and relative weight of the liver, kidneys and brain of broilers. Any damages were not observed after the histopathological exams of these organs regardless the diet considered, compared to the control group. All results ranging from efficacy and safety of cassava cortex extract containing scopoletin and cyanide allowed us to consider it as biopesticide for staple food preservation against post-harvest losses.
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