Abstract
THIS work began in Cambridge in 1939 with the original purpose of preparing compounds of the type PbiR4 which might be toxic by inhalation. It should be noted that, at that time, supplies of arsenic in Great Britain were very much reduced, whereas lead was readily available. Compounds which we contemplated preparing were (C2H5)2Pb(CH2CH = CH2)2, (C2H5)2Pb(CH2CH2Cl)2 and Pb(CH2CH2Cl)4, etc. As an intermediate, it was necessaryto prepare triethyl lead chloride (C2H5)3PbCl in quantity, and one of us (B. C. S.), while working with thiscompound, developed the symptoms of a severe attack ofinfluenza, which, however, wore off at night and returned during the day. The compound was therefore tested for sternutatory properties, and found to produce, at a concentration of one part in a million, an atmosphere in which respiration was difficult.
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