Abstract
The study examined effects of Ochratoxin-A (OTA) and Endosulfan on the haemato-biochemical changes in rats. Adult male Wistar rats were randomly divided into four groups and fed OTA @ 4 ppm in feed (Group I); endosulfan @ 5 mg/kg body weight in corn oil by oral intubation (Group II); combination of both endosulfan @ 5 mg/kg body weight in corn oil and OTA @ 4 ppm in feed (Group III) and toxin free feed (Group IV - control group) daily for 30 days. After treatment, blood was collected from heart for studying haemato-biochemical indices. All toxin treated rats showed a significant (P<0.05) decrease in the body weights. The treated rats became anemic (normocytic hypochromic anemia) and also revealed lympho cytopenic-leukopenia. Biochemical changes included significant decline in, serum globulin, total protein and albumin along with concurrent increased levels of blood glucose, AST and ALT. Spleen of the treated animals showed depletion of lymphocytes on light microscopy. The present investigation revealed significant toxicity in combination group in comparison to single exposure to OTA or endosulfan alone (Group I and Group II, respectively). These findings suggest that concurrent exposure to endosulfan and OTA results in additive toxic manifestation on haemato-biochemical parameters in male rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
