Toxic epidermal necrolysis: 10 years experience of a burns centre in Hong Kong

Abstract

Toxic epidermal necrolysis syndrome is characterized by extensive skin rash with blisters and exfoliation similar to that of major burns. Current evidence suggests that toxic epidermal necrolysis syndrome is most likely due to cell-mediated immune response triggered by certain drugs. Recognition of the clinical situation which is similar to major burn has resulted in general agreement that these patients are best treated in a burns unit, where critical support and meticulous wound care can be carried out by experienced personnel. This represents a major step forward in the management of this condition. The 10 year experience of managing seven patients with severe toxic epidermal necrolysis in a tertiary burns centre in Hong Kong is presented and the controversies over classification and management of the disease are also discussed.