Abstract
The aim of this study was to determine what changes in biochemical parameters and in the antioxidant capacity occur in the brain of arsenic-exposed rats (50mg As/L in drinking water) and investigate the protective effect of antioxidants as Zn, vitamin C and vitamin E during pregnancy and lactation. After arsenic-exposure, alkaline phosphatase (ALP) activity was enhanced in arsenic group, returning to normal levels in the arsenic+antioxidants one. A significant increase of acetylcholinesterase (AChE) activity was noted in both arsenic groups. Metalloide exposure caused a significant increase in lipid peroxidation (TBARS), whereas antioxidant administration reversed it. Catalase (CAT) activity in arsenic groups was increased, but no changes were found in the other groups. No significant effect of arsenic in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and reduced glutathione concentration (GSH) was noted. This study provides evidence of the deleterious effect of arsenic exposure during gestation and lactation and the beneficial role of antioxidants.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
