Abstract

Subsequent to the publication of the 1st Report of the Toxicity Working Party at the International Chlorine Symposium organised by the SCI in 1985 in London, and its publication in book form [1], CEFIC commissioned a special study [2] at the TNO-CIVO laboratories in Zeist, The Netherlands. Its primary aim was to obtain data using rats which would establish an LC low or threshold LC. The protocol also included sufficient work with mice to provide a comparison with earlier work described in the literature. It will be recalled that the Working Party, in its earlier report, had been unable to draw any conclusions about the concentrations likely to cause low percentage fatalities, although it did make the positive statement that no lethalities have been demonstrated at 30 min exposure time at or below 50 ppm for any species.

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