Abstract
It has been demonstrated by several investigators1-7 that mono-iodoacetic acid will react with sulfhydryl groups, presumably according to the following equation—RSH + CH2ICOOH → R-S-CH2COOH + HIThat this reaction may have important biological applications is evident from the demonstration that the poisonous effect of iodoacetic acid on the action of the enzyme glyoxalase has been shown2 to be due to the removal of the co-ferment, reduced glutathione.8It is also known that some organic arsenicals react with thiol compounds forming condensation products,9 and according to the theory of Voegtlin arsenicals exert their toxic effect upon trypanosomes by combining with sulfhydryl groups present in and, in his opinion, essential for the oxygen consumption of these organisms. If the above considerations are correct, it would seem to follow, necessarily, that iodoacetic acid must be toxic to trypanosomes.In vitro experiments, carried out to test the above conclusion, showed that sodium iodoacetate added to Trypano...
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