Abstract
In the course of this study, an analysis was made of the current foreign and domestic literature on the problem of the toxic effect of local anesthetics on the human body. Literature search was carried out in such databases as PubMed, eLibrary, CyberLeninka. Local anesthetics are widely used in modern clinical practice to anesthetize the area of surgical intervention, as well as symptomatic treatment of some pathologies that are characterized by severe pain. In today's world, an average of 10% of patients develop adverse reactions when using drugs. The level of toxicity of a particular compound is determined by the level of its toxic dose – the amount of a substance that causes some toxic effect. Thus, the greater the toxicity of a chemical, the lower its toxic dose will be. At present, a wide range of drugs for local anesthesia has been developed that have minimal side effects, despite this, we must not forget about the toxic effect on the body of this group of drugs, and therefore it is necessary to apply a personalized approach to each specific patient when performing local anesthesia, regardless of complexity. performed surgical intervention.
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