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Abstract
The study of biological activity of extracts from roots and rhizomes of male fern Dryopteris filix-mas was carried out in experiments with soil nematode Caenorhabditis elegans. The toxicity of extracts of D. filix-mas roots and rhizomes obtained by different methods varied over a wide range. Crude extract of male fern roots and rhizomes in concentration range 62.5–250 µg/ml had a weak toxic action on C. elegans organism by inducing death of 26.0–43.3% nematodes. The toxicity of relatively high concentrations (500 and 250 µg/ml) of water-ethanolic extracts might be compared with such of crude extract in concentrations 62.5–250 µg/ml. Biological activity of filicinic acids ethers was found very high: concentrations of crude extract of D. filix-mas roots and rhizomes and concentrations of filicinic acids ethers with similar toxicity for C. elegans organism were 40-fold different. Substances isolated from D. filix-mas roots and rhizomes have nematicidal activity and may be used for development of drugs to treat helminthiasis of humans and animals.
Highlights
Helminthiases are one of the most common diseases of livestock and domestic pets
Soil nematode C. elegans is very sensitive to most modern synthetic drugs using for treatment of human and animals’ helminthiases
Biological activity of crude extract was similar with biological activity of aqueousethanolic extracts
Summary
Helminthiases are one of the most common diseases of livestock and domestic pets. Animals infected by helminths decline their producing capacity. Helminths infections make animals more vulnerable to other diseases owing to immunity impairment. Helminthiases may cause lesion of eyes, gastrointestinal tract, cardiovascular and respiratory systems of humans. Not less than two billion people are affected by different helminthiases, and most of these people live in tropical and subtropical regions [1]. Helminthiases are serious problem for medicine, and for veterinary medicine. The weight of animals infected by helminths is reduced for 3–8%, and their death increases by about 28% [2]
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