Abstract
Water in oil droplets has been an important research topic because of the possibility of small-volume biochemical reaction vessels in which the reaction time and chemical concentration can be precisely controlled. Here, a new method for producing femtoliter-scale (10−17 L) aqueous droplets on-demand has been developed based on pressure driven formation of droplets at the intersection of microchannels. Different aqueous solutions in two apposed microchannels with 1 micrometer in width were forced into an oil-filled microchannel to form two aqueous droplets, which then collided with each other to start biochemical reactions by diffusional/convectional mixing. These monodisperse micro-reactors can enable the characterization of catalytic or biochemical reaction dynamics in confined environments, as well as the development of reaction vessels for highly localized sampling and dosing.
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