Abstract
Electrical excitability is a fundamental property of the neuromuscular systems of metazoans. The varied response of neurons to electrical excitation is largely accounted for by a diverse set of voltage-gated potassium (K V) channels in the excitable membrane. The complete structure of a K V channel is not yet available. However, recent structural biological experiments have begun to provide new insight into how specific K V channels are formed and regulated, and how they function and interact with other proteins. In particular, the selectivity of K V channels for K + and suggestions as to how these structural elements might assemble into a functional K V channel are discussed.
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