Abstract
Process Analytical Technologies (PAT) are increasingly being explored and adopted by pharma-chem and bio-pharma companies for enhanced process understanding, Quality by Design (QbD) and Real-time-Release (RTR). To achieve these aspirations there is a critical need to extract the most information, and hence understanding, from complex and often very ‘messy’ spectroscopic data. A number of new approaches will be shown to overcome the limitations of existing calibration/modelling methodologies and algorithms and their use in some industrial applications will be presented.
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