Abstract
Tumor hypoxia is strongly correlated with treatment failure. In an earlier study, we used a quantitative model to investigate the effect of radiation fractionation on tumor cell killing for realistic distributions of tumor oxygenation. In this study, the effects of tumor hypoxia, DNA damage repair, and repopulation are investigated. The impact of uncertainties in DSB rejoining and cell growth kinetics with oxygen concentration is evaluated.
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More From: International Journal of Radiation Oncology*Biology*Physics
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