Towards SI-traceability of lipoprotein (a) measurements: Comparison of a candidate LC-MRM-MS RMP method with commercially available immunoassays for evaluating commutability of candidate reference materials

Ioannis Dikaios ,L Deprez,H Althaus,E Angles-Cano,T Boesche,A.N Lyle,Z Kuklenyik,J Dittrich ,B Dieplinger ,S Coassin ,A Hoofnagle ,R Ruhaak ,H.w Vesper ,U Ceglarek ,I.b Brkovic ,U Prinzing ,F Kronenberg ,G Kostner ,H Scharnagl ,V Delatour ,C Cobbaert

doi:10.1016/j.atherosclerosis.2022.06.395

Towards SI-traceability of lipoprotein (a) measurements: Comparison of a candidate LC-MRM-MS RMP method with commercially available immunoassays for evaluating commutability of candidate reference materials

Ioannis Dikaios , L Deprez + Show 19 more

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https://doi.org/10.1016/j.atherosclerosis.2022.06.395

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Journal: Atherosclerosis

Publication Date: Aug 1, 2022

Affiliation: University Hospital Leipzig, Ordensklinikum Linz Barmherzige Schwestern, Convent Hospital of the Brothers of Saint John of God, Innsbruck Medical University, Universität Innsbruck, Seattle University, University of Washington, European Commission, Siemens Healthcare (Germany), Leiden University Medical Center, Université Paris Cité, Inserm, Centers for Disease Control and Prevention, Leipzig University, Roche (Germany), Medical University of Graz, Laboratoire National de Métrologie et d'Essais

#Elevated Concentrations Of Lipoprotein #Reference Measurement System + Show 8 more

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Abstract

Background and Aims : Elevated concentrations of lipoprotein(a) (Lp(a)) are directly related to an increased risk of cardiovascular diseases, thus making its determination a crucial factor for clinical diagnosis. However, the lack of global standardisation of current immunoassay-based measuring procedures (MPs) for Lp(a) leads to inconsistent care of patients. The former Lp(a) reference method and the associated WHO-IFCC reference material are no longer available. Recently, it was decided to evolve to a next generation reference measurement system (RMS) with SI-traceability.

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