Abstract

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

Highlights

  • The history of innovative laser applications demonstrates its ubiquitous character

  • Since this is a review of progress toward laser-driven radiotherapy it is useful to know if and how the biological effect of particle radiation generated by lasers differs from that provided by conventional accelerators

  • Before discussing in detail where we are with laser driven ion beams for oncology, we comment briefly on possible controversies concerning the effectiveness of ion beam radiotherapy in general

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Summary

A Review of Progress

Bolton 3, Naoya Shikazono 4 and C.-M. SUPA, Department of Physics, University of Strathclyde, Glasgow G40NG, Scotland, UK. Received: 18 June 2014; in revised form: 1 August 2014 / Accepted: 4 August 2014 /

Preamble
Introduction
Typical Ion Energy Spectra
Beam Transport and Delivery Considerations
Laser Driven Electron Beams for Radiotherapy
Cellular Basis of Laser-driven Radiation Therapy
Important Factors for Determining Cellular Radiation Effect
DNA Damage Sequence and Biological Effects
Dose Rate Picture
Oxygen Effect and Dose Rate
Laser-driven Radiation in Radiobiological Studies
Queens University Belfast Consortium
Ion Acceleration Program at BNL ATF and UCLA
Laser-Acceleration Studies at JAEA in Japan
ELIMED Prague
Comparative Radiotherapy Costs
Findings
10. Discussion and Conclusions
Full Text
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