Abstract
Image texture is increasingly used to discriminate tissues and lesions in PET/CT. For quantification or in computer-aided diagnosis, textural feature analysis must produce robust and comparable values. Because statistical feature values depend on image count statistics, we investigated in depth the stability of Haralick features values as functions of acquisition duration, and for common image resolutions and reconstructions. A homogeneous cylindrical phantom containing 9.6 kBq/ml Ge-68 was repeatedly imaged on a Siemens Biograph mCT, with acquisition durations ranging from three seconds to three hours. Images with 1.5, 2, and 4 mm isometrically spaced voxels were reconstructed with filtered back-projection (FBP), ordered subset expectation maximization (OSEM), and the Siemens TrueX algorithm. We analysed Haralick features derived from differently quantized (3 to 8-bit) grey level co-occurrence matrices (GLCMs) as functions of exposure E, which we defined as the product of activity concentration in a volume of interest (VOI) and acquisition duration. The VOI was a 50 mm wide cube at the centre of the phantom. Feature stability was defined for df/dE → 0. The most stable feature values occurred in low resolution FBPs, whereas some feature values from 1.5 mm TrueX reconstructions ranged over two orders of magnitude. Within the same reconstructions, most feature value-exposure curves reached stable plateaus at similar exposures, regardless of GLCM quantization. With 8-bit GLCM, median time to stability was 16 s and 22 s for FBPs, 18 s and 125 s for OSEM, and 23 s, 45 s, and 76 s for PSF reconstructions, with longer durations for higher resolutions. Stable exposures coincided in OSEM and TrueX reconstructions with image noise distributions converging to a Gaussian. In FBP, the occurrence of stable values coincided the disappearance of negatives image values in the VOI. Haralick feature values depend strongly on exposure, but invariance exists within defined domains of exposure. Here, we present an easily replicable procedure to identify said stable exposure domains, where image noise does not substantially add to textural feature values. Only by imaging at predetermined feature-invariant exposure levels and by adjusting exposure to expected activity concentrations, can textural features have a quantitative use in PET/CT. The necessary exposure levels are attainable by modern PET/CT systems in clinical routine.
Highlights
Positron emission tomography in conjunction with computed tomography (PET-CT) is an imaging modality that quantifies radiotracer uptake in the living organism
Haralick features vary with image noise, but exposure-invariant domains enable comparable PET radiomics measured the selected textural features within the same central region of the cylindrical phantom for seven clinical image reconstruction protocols, testing our hypothesis that textural feature values are highly variable depending on image noise, resolution, and reconstruction procedures
While activity histograms reconstructed with filtered back-projection (FBP) tended be wider than were those from point spread function (PSF) reconstructions, the former were more Gaussian in Haralick features vary with image noise, but exposure-invariant domains enable comparable PET radiomics shape, even at brief acquisitions
Summary
Positron emission tomography in conjunction with computed tomography (PET-CT) is an imaging modality that quantifies radiotracer uptake in the living organism. The PET/CT system‘s spatially resolved measurements reveal textural features, yielding a metric for quantifying an imaged object’s structure [1]. Textural feature analysis increases the information retrievable from PET/CT images, which is useful for characterizing and classifying tissue and lesions according to differences in morphology [2]. Adding texture analysis to a PET/CT readout can improve diagnostic sensitivity and specificity for certain tumor entities [3]. Textural features are exploited as a surrogate measure of tissue metabolic heterogeneity [4], which can be an index of tumor malignancy, for example in the case of thymic epithelial cancer [5]. Expanding the feature space of PET/CT images makes texture analysis useful for pattern recognition techniques [7] and computer-assisted diagnosis (CAD)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.