Towards gene therapy for the treatment of rheumatoid arthritis: production and bioactivity of interferon β in fibroblast-like synoviocytes transduced with adeno-associated virus type 5 expressing human interferon β

Abstract

Background and objectivesThe authors are developing local intra-articular gene therapy for the treatment of rheumatoid arthritis (RA) using human interferon β (hIFNβ) as therapeutic gene expressed under control of an...