Abstract
Single Molecule Super-resolution imaging has revolutionised understanding biological processes on the sub-100 nm scale. Our group developed Fluorophore Localisation Imaging with Photobleaching (FLImP), a super-resolution imaging method that can achieve <4 nm resolution. In concert with molecular dynamics simulations, FLImP was used to reveal the in-situ atomic resolution structures of ligand-bound EGFR oligomers at the plasma membrane of cells (Needham et al., Nat Comms 2016), and those of ligand-unbound dimers and oligomers on cells (Zanetti-Domingues et al., Nat Comms 2018), shedding new light on the mechanisms of EGFR auto-inhibition, phosphorylation and signalling.
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