Abstract
MRI can be used to generate fat fraction (FF) and R2* data, which have been previously shown to characterize the plaque compositional features lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in the carotid arteries (CAs). Previously, these data were extracted from CA plaques using time-consuming manual analyses. To design and demonstrate a method for segmenting the CA and extracting data describing the composition of the vessel wall. Prospective. 31 subjects from the Swedish CArdioPulmonary bioImage Study (SCAPIS). T1 -weighted (T1 W) quadruple inversion recovery, contrast-enhanced MR angiography (CE-MRA), and 4-point Dixon data were acquired at 3T. The vessel lumen of the CA was automatically segmented using support vector machines (SVM) with CE-MRA data, and the vessel wall region was subsequently delineated. Automatically generated segmentations were quantitatively measured and three observers visually compared the segmentations to manual segmentations performed on T1 w images. Dixon data were used to generate FF and R2* maps. Both manually and automatically generated segmentations of the CA and vessel wall were used to extract compositional data. Two-tailed t-tests were used to examine differences between results generated using manual and automated analyses, and among different configurations of the automated method. Interobserver agreement was assessed with Fleiss' kappa. Automated segmentation of the CA using SVM had a Dice score of 0.89 ± 0.02 and true-positive ratio 0.93 ± 0.03 when compared against ground truth, and median qualitative score of 4/5 when assessed visually by multiple observers. Vessel wall regions of 0.5 and 1 mm yielded compositional information similar to that gained from manual analyses. Using the 0.5 mm vessel wall region, the mean difference was 0.1 ± 2.5% considering FF and 1.1 ± 5.7[1/s] for R2*. 1. 1. J. Magn. Reson. Imaging 2020;52:710-719.
Highlights
Magnetic resonance imaging (MRI) can be used to generate fat fraction (FF) and R2* data, which have been previously shown to characterize the plaque compositional features lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in the carotid arteries (CAs)
In this work we aimed to design and demonstrate a method for segmenting the carotid arteries and extracting data describing the composition of the vessel wall, by examining FF and R2*, with minimal user input
Study participants were between 50 and 64 years old and had nonsymptomatic atherosclerotic plaques of at least 2.7 mm as measured by ultrasound. Data from both carotid arteries was used, study participants most frequently presented with unilateral plaque
Summary
MRI can be used to generate fat fraction (FF) and R2* data, which have been previously shown to characterize the plaque compositional features lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in the carotid arteries (CAs). These data were extracted from CA plaques using time-consuming manual analyses. Assessment: The vessel lumen of the CA was automatically segmented using support vector machines (SVM) with CEMRA data, and the vessel wall region was subsequently delineated. Dixon data were used to generate FF and R2* maps Both manually and automatically generated segmentations of the CA and vessel wall were used to extract compositional data.
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