Towards Accurate and Robust MRSI Quantification to Improve the Radiation Therapy Treatment of GBM

Abstract

MR spectroscopic imaging (MRSI) can characterize biochemical, metabolic and pathological changes in brain tissues before they are visible from conventional anatomical images. This makes MRSI a powerful tool to define biologically tailored target volumes for dose escalation in radiation therapy treatments. Although the numerous existing quantification techniques, it remains difficult to obtain accurate information from MRSI signals due to biological and experimental conditions decreasing the quality of the data.