Abstract
Cyclic lipodepsipeptides (CLiPs) are a class of secondary metabolites produced by soil-borne bacteria such as Pseudomonas spp. that share a common blueprint, namely: a relative short oligopeptide sequence where the N-terminus is acylated with a fatty acid moiety. The ester bond establishes the macrocyclic nature by involving the C-terminus and a hydroxyl functionality. A great incentive for researching these unique molecules has been their pronounced biological activity profile. Aside from their beneficial traits to their natural ecological niche (e.g bioremediation, plant promoting potential,..) it was found that they offer tremendous potential in the fight against multi-resistant bacteria.
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