Abstract
The application of force to reagents that participate in a chemical reaction can probe the transition state of the reaction with sub-Angstrom resolution. Using single-molecule force-clamp spectroscopy, this approach has been extensively applied to the cleavage of disulfide bonds in proteins. However, to date there is no methodology that can expand this class of experiments to bonds not naturally present in proteins. Here, we introduce an experimental platform with the potential to fulfill the requirements to perform single-bond rupture determinations on any covalent bond.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
