Abstract
Lipid bilayers and efflux transporters like P-glycoprotein (P-gp) represent the most important in vivo barriers for therapeutic agents. Driven by ATP hydrolysis, P-gp exports structurally diverse hydrophobic compounds from the cell reducing intestinal absorption and blood-brain barrier passage. P-gp expression has also been linked to the efflux of chemotherapeutic drugs in human cancer cells, contributing to multidrug resistance.
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