Abstract
Background The repertoire of known histone modifications is far from complete. Most attention has been focused on the N-terminal histone tails. However, modifications on the lateral surface of the histone octamer can potentially directly regulate nucleosome dynamics. Because of their structurally important position close to the DNA, we can understand what these modifications are actually doing to nucleosome structure and/or dynamics.
Highlights
The repertoire of known histone modifications is far from complete
By applying a genome-wide approach we find that H3K122ac defines genetic elements associated with transcription and that it co-occurs with active chromatin marks
To investigate if H3K122ac correlates with active transcription, but has a causative function, we developed an in vitro protocol to transcribe chromatin with defined acetylations
Summary
The repertoire of known histone modifications is far from complete. Most attention has been focused on the N-terminal histone tails. Towards a causative function of histone modifications in regulation of chromatin dynamics and transcription From Epigenetics and Chromatin: Interactions and processes Boston, MA, USA.
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