Abstract
Abstract The tetrahydropyranone 3 , representing a pentacyclic C4–C32 segment of the phorboxazoles, was obtained by a complex hetero Diels–Alder (HDA) coupling performed between the 2-siloxydiene 23 and the oxazole aldehyde 4 , mediated by the chiral tridentate Cr(III) catalyst 14 . In preliminary studies, the tetrahydropyrans 17 , 33 and 35 were accessed using this same asymmetric HDA methodology with varying stereoselectivity.
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