Toward long, all-atom simulation of the E. coli 70S ribosome

Abstract

The precise machinery of large ribosomal complexes underlies the fundamental process of translation from RNA to protein in biology. In order for an amino acid to be incorporated into a growing polypeptide chain in both an accurate and efficient manner, the various components of the ribosome must coordinate in a dynamic interplay that moves the ribosome through the states of the elongation cycle. A deeper understanding of these processes at atomic resolution can potentially be achieved through the use of long-timescale molecular dynamics simulations.