Abstract
The Early Detection Research Network (EDRN) has the mission to identify and validate biomarkers for clinical use. The Genitourinary Collaborative Group within EDRN has developed a robust triage and validation system that serves both “facilitator” and “brake” roles. The system consists of the establishment of a reference set of specimens collected under Prospective-specimen-collection-Retrospective-Blinded-Evaluation (PRoBE) design criteria, use of this reference set to pre-validate candidate biomarkers before committing a full-scale validation study, and expansion of this reference set for a full-scale validation study for future biomarkers. This reference set could also be expanded for biomarker discovery purposes.
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