Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology

Abstract

Located medially within the temporal lobes, the amygdala is a formation of heterogenous nuclei that has emerged as a target for investigations into the neural bases of both primitive and complex behaviors. Although modern neuroscience has eschewed the practice of assigning broad functions to distinct brain regions, the amygdala has classically been associated with regulating negative emotional processes (such as fear or aggression), primarily through research performed in rodent models. Contemporary studies, particularly those in non-human primate models, have provided evidence for a role of the amygdala in other aspects of cognition such as valuation of stimuli or shaping social behaviors. Consequently, many modern perspectives now also emphasize the amygdala’s role in processing positive affect and social behaviors. Importantly, several recent experiments have examined the intersection of two seemingly autonomous domains; how both valence/value and social stimuli are simultaneously represented in the amygdala. Results from these studies suggest that there is an overlap between valence/value processing and the processing of social behaviors at the level of single neurons. These findings have prompted researchers investigating the neurophysiological mechanisms underlying social interactions to question what contributions reward-related processes in the amygdala make in shaping social behaviors. In this review, we will examine evidence, primarily from primate neurophysiology, suggesting that value-related processes in the amygdala interact with the processing of social stimuli, and explore holistic hypotheses about how these amygdalar interactions might be instantiated.