Abstract
The total synthesis of the resorcylic acid lactones (-)-zearalenone and (-)-zearalanone is described. Our synthetic strategy relies on Ni-, Zr-, and Cr-mediated intramolecular reductive ketone coupling to create 14-membered macrolactones. Notably, the use of CrCl2 in addition to Ni/Zr-mediated reductive ketone coupling conditions was key for the success of the macrocyclization.
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