Abstract
Sharpless epoxidation of the readily available dienol 2 , followed by regiospecific opening with Me 2CuLi/BF 3·Et 2O yields, after protecting group manipulation, the monoprotected diol 10c . Swern oxidation gives the cyclic carbaminol 14a which is easily manipulated to α-cyano oxazolidinone 15 and thus, by literature methods, to the title compound. Using this procedure, good overall yield and high enantiomeric purity are obtained.
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