Abstract
Nicotinic acetylcholine receptors (nAChRs) play important roles in intercellular communications of nerve cells. α-Bungarotoxins (αBtx) is a moderator for the nAChRs. Chemical synthesis provides a promising way to access αBtx and their analogues. Here, we reported a new method for α-bungarotoxin by combining Fmoc-SPPS and peptide hydrazide based ligation strategy. The two-segment ligation method may enable efficient synthesis of αBtx analogues. These synthetic toxin peptides are useful tools for development of imaging or therapeutic reagents.
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