Abstract
AbstractThe first enantioselective total synthesis of a polyhydroxylated macrolide, (+)‐seimatopolide A, was achieved. The key reactions, Sharpless asymmetric dihydroxylation, Yamaguchi esterification, and ring‐closing metathesis, provided easy access to the target molecule from L‐aspartic acid. Further, the absolute stereochemistry of the natural product has also been revised.
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