Abstract
Two protocols have been developed for the Pd-catalyzed regioselective synthesis of 4-aryl-3-chloro-2(5 H)-furanones starting from 3,4-dichloro-2(5 H)-furanone. These monochloro derivatives have then been used as precursors to ( Z)-4-aryl-5-[1-(aryl)methylidene]-3-chloro-2(5 H)-furanones including naturally-occurring rubrolide M.
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