Abstract
The enantioselective synthesis of ( R)-(−)-actisonitrile 1 has been achieved via O-alkylation of (4 R,α S)-4-hydroxymethyl-3-(α-methylbenzyl)oxazolidin-2-one (α S)- 4 with 1-iodohexadecane in the presence of CsOH in DMF. Under these reaction conditions, the O-alkylation was much faster than the intramolecular acyl transfer of (α S)- 4.
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