Total Synthesis of Phorboxazole B

Abstract

Challenge met: In the synthesis of phorboxazole B, a highly efficient hetero-Diels–Alder reaction was used to construct the key C33–C39 linchpin, allowing for the completion of the C18–C46 fragment (see picture). Coupling with a suitable C3–C17 partner was followed by late-stage formation of the oxazole unit, macrocyclization, and deprotection to afford synthetic phorboxazole B. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603656_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.