Abstract
Starting from 7-hydroxy-6-methoxy-indole (III) PDE-II (II), a new inhibitor of cyclic adenosine 3′,5′-monophosphate phosphodiesterase and the first substance which has 1,2-dihydro-3H-pyrrolo[3,2-e]indole skelton, was synthesized in eight steps. The key intermediate, 1-acetyl-5-amino-2,3-dihydro-7-hydroxy-6-methoxy-indole (VIII), carring necessary substituents was obtained from III in five steps. Coupling of the diazoniumsalt of VIII with ethyl 2-acetylpropionate followed by acid catalized cyclization and alkaline hydrolysis afforded II.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
