Total Synthesis of (±)-Parvineostemonine

Abstract

Roots and rhizomes of the stemonaceous plant have long been used for the treatment of respiratory diseases and as domestic insecticides in traditional folk medicine of East Asia. So far, over 130 structurally diverse Stemona alkaloids have been isolated from the monocotyledonous family Stemonaceae. These Stemona alkaloids have fascinating architectures and potential biological activities, which have provoked broad interests in their total synthesis. Among the Stemona alkaloids, parvineostemonine (1a), isolated from Stemona parviflora by Ye and co-workers in 2003, is a unique molecule which differs from the typical Stemona alkaloids such as 1b–1e (Figure 1). Parvineostemonine fea-